| Gruppo | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| # | Gruppo Ovest | PG | V | N | P | R | DR | P | Forma |
| 1. | San Diego FC | 17 | 12 | 1 | 4 | 39:24 | 15 | 37 | |
| 2. | Minnesota | 17 | 8 | 6 | 3 | 27:19 | 8 | 30 | |
| 3. | Vancouver Whitecaps | 17 | 8 | 5 | 4 | 24:18 | 6 | 29 | |
| 4. | Los Angeles FC | 17 | 6 | 7 | 4 | 34:27 | 7 | 25 | |
| 5. | FC Dallas | 17 | 5 | 8 | 4 | 27:30 | -3 | 23 | |
| 6. | San Jose Earthquakes | 17 | 6 | 2 | 9 | 23:31 | -8 | 20 | |
| 7. | Austin FC | 17 | 6 | 1 | 10 | 19:29 | -10 | 19 | |
| 8. | Seattle Sounders | 17 | 5 | 4 | 8 | 20:28 | -8 | 19 | |
| 9. | Houston Dynamo | 17 | 4 | 7 | 6 | 23:26 | -3 | 19 | |
| 10. | Portland Timbers | 17 | 4 | 5 | 8 | 16:22 | -6 | 17 | |
| 11. | St. Louis City | 17 | 4 | 2 | 11 | 21:30 | -9 | 14 | |
| 12. | Real Salt Lake | 17 | 3 | 4 | 10 | 15:28 | -13 | 13 | |
| 13. | Colorado Rapids | 17 | 3 | 4 | 10 | 19:35 | -16 | 13 | |
| 14. | Sporting Kansas City | 17 | 3 | 2 | 12 | 21:38 | -17 | 11 | |
| 15. | Los Angeles Galaxy | 17 | 0 | 7 | 10 | 19:38 | -19 | 7 | |
| # | Gruppo Est | PG | V | N | P | R | DR | P | Forma |
| 1. | Cincinnati | 17 | 11 | 2 | 4 | 25:21 | 4 | 35 | |
| 2. | Chicago Fire | 17 | 9 | 2 | 6 | 43:35 | 8 | 29 | |
| 3. | Inter Miami | 17 | 8 | 5 | 4 | 37:29 | 8 | 29 | |
| 4. | Philadelphia Union | 17 | 8 | 2 | 7 | 21:20 | 1 | 26 | |
| 5. | Orlando City | 17 | 6 | 7 | 4 | 27:25 | 2 | 25 | |
| 6. | New York City | 17 | 6 | 5 | 6 | 22:23 | -1 | 23 | |
| 7. | Columbus Crew | 17 | 5 | 7 | 5 | 26:31 | -5 | 22 | |
| 8. | New England Revolution | 17 | 5 | 5 | 7 | 24:26 | -2 | 20 | |
| 9. | Charlotte | 17 | 6 | 1 | 10 | 22:30 | -8 | 19 | |
| 10. | Nashville SC | 17 | 5 | 3 | 9 | 22:28 | -6 | 18 | |
| 11. | CF Montreal | 17 | 4 | 4 | 9 | 20:27 | -7 | 16 | |
| 12. | Toronto FC | 17 | 3 | 7 | 7 | 20:25 | -5 | 16 | |
| 13. | DC United | 17 | 3 | 4 | 10 | 17:35 | -18 | 13 | |
| 14. | New York Red Bulls | 17 | 2 | 4 | 11 | 12:24 | -12 | 10 | |
| 15. | Atlanta Utd | 17 | 1 | 5 | 11 | 9:34 | -25 | 8 | |