| Gruppo | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| # | Gruppo Ovest | PG | V | N | P | R | DR | P | Forma |
| 1. | Vancouver Whitecaps | 8 | 7 | 0 | 1 | 21:4 | 17 | 21 | |
| 2. | Real Salt Lake | 8 | 7 | 0 | 1 | 18:8 | 10 | 21 | |
| 3. | Los Angeles FC | 8 | 5 | 1 | 2 | 15:8 | 7 | 16 | |
| 4. | Houston Dynamo | 7 | 5 | 0 | 2 | 8:6 | 2 | 15 | |
| 5. | San Jose Earthquakes | 7 | 4 | 1 | 2 | 16:6 | 10 | 13 | |
| 6. | Seattle Sounders | 6 | 4 | 1 | 1 | 12:7 | 5 | 13 | |
| 7. | FC Dallas | 9 | 3 | 4 | 2 | 18:16 | 2 | 13 | |
| 8. | San Diego FC | 9 | 3 | 3 | 3 | 23:15 | 8 | 12 | |
| 9. | Austin FC | 7 | 3 | 2 | 2 | 9:6 | 3 | 11 | |
| 10. | St. Louis City | 6 | 3 | 1 | 2 | 11:7 | 4 | 10 | |
| 11. | Portland Timbers | 6 | 3 | 1 | 2 | 14:11 | 3 | 10 | |
| 12. | Colorado Rapids | 6 | 3 | 0 | 3 | 15:9 | 6 | 9 | |
| 13. | Los Angeles Galaxy | 7 | 2 | 3 | 2 | 10:8 | 2 | 9 | |
| 14. | Minnesota | 7 | 2 | 3 | 2 | 6:5 | 1 | 9 | |
| 15. | Sporting Kansas City | 7 | 1 | 2 | 4 | 9:14 | -5 | 5 | |
| # | Gruppo Est | PG | V | N | P | R | DR | P | Forma |
| 1. | New England Revolution | 8 | 7 | 0 | 1 | 17:7 | 10 | 21 | |
| 2. | Nashville SC | 7 | 6 | 1 | 0 | 23:9 | 14 | 19 | |
| 3. | Charlotte | 9 | 5 | 2 | 2 | 18:9 | 9 | 17 | |
| 4. | Chicago Fire | 8 | 5 | 0 | 3 | 16:9 | 7 | 15 | |
| 5. | Cincinnati | 7 | 4 | 1 | 2 | 20:14 | 6 | 13 | |
| 6. | New York City | 8 | 3 | 2 | 3 | 19:13 | 6 | 11 | |
| 7. | Columbus Crew | 7 | 3 | 2 | 2 | 9:6 | 3 | 11 | |
| 8. | New York Red Bulls | 7 | 3 | 2 | 2 | 13:14 | -1 | 11 | |
| 9. | Toronto FC | 9 | 2 | 5 | 2 | 17:18 | -1 | 11 | |
| 10. | CF Montreal | 6 | 3 | 1 | 2 | 10:7 | 3 | 10 | |
| 11. | Orlando City | 7 | 3 | 1 | 3 | 14:13 | 1 | 10 | |
| 12. | Inter Miami | 6 | 2 | 3 | 1 | 16:13 | 3 | 9 | |
| 13. | DC United | 7 | 2 | 2 | 3 | 11:16 | -5 | 8 | |
| 14. | Atlanta Utd | 8 | 2 | 1 | 5 | 11:14 | -3 | 7 | |
| 15. | Philadelphia Union | 6 | 0 | 3 | 3 | 3:6 | -3 | 3 | |